Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. 3D bioprinted functional and contractile cardiac tissue constructs. Recreating the heart’s helical structure-function relationship with focused rotary jet spinning. Jetvalve: rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement. A tissue-engineered scale model of the heart ventricle. Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. A photolithographic method to create cellular micropatterns. Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Muscular thin films for building actuators and powering devices. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Modeling the mitochondrial cardiomyopathy of barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue.

Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Advanced maturation of human cardiac tissue grown from pluripotent stem cells. in Interstitial Fibrosis in Heart Failure (ed. Functional properties of engineered heart slices incorporating human induced pluripotent stem cell-derived cardiomyocytes. The resulting 3D-printed ventricle in vitro model exhibited biomimetic anisotropic electrophysiological and contractile properties.įrantz, C., Stewart, K. Shear-induced alignment of fibres during ink extrusion provides microscale geometric cues that promote the self-organization of cultured human cardiomyocytes into anisotropic muscular tissues in vitro. The addition of prefabricated gelatin fibres to hydrogels enables the tailoring of the ink rheology, allowing for a controlled sol–gel transition to achieve precise printing of free-standing 3D structures without additional supporting materials. Here we develop a hydrogel ink containing prefabricated gelatin fibres to print 3D organ-level scaffolds that recapitulate the intra- and intercellular organization of the heart. Hydrogels are attractive materials for tissue engineering, but efforts to date have shown limited ability to produce the microstructural features necessary to promote cellular self-organization into hierarchical three-dimensional (3D) organ models.

Stl files for 3d printing bicycles